Journal: Scientific Reports
Article Title: Copy-number amplification drives IFI30 overexpression and coordinated immune activation, identifying a novel diagnostic and therapeutic target in gastric adenocarcinoma
doi: 10.1038/s41598-026-37574-z
Figure Lengend Snippet: Expression pattern and diagnostic value of IFI30 in stomach adenocarcinoma (STAD). A Pan-cancer integrated analysis of TCGA and GTEx datasets showing significantly elevated IFI30 mRNA levels in STAD tissues compared with normal gastric tissues. B Paired-sample analysis from the TCGA cohort confirming consistently higher IFI30 expression in gastric cancer tissues relative to matched adjacent normal tissues. C Multi-tissue heat-map visualization based on the pan-cancer TCGA-GTEx database demonstrates up-regulation of IFI30 across gastrointestinal and immune-related malignancies, with the most pronounced elevation in STAD. D Immunofluorescence images from the Human Protein Atlas (HPA) showing robust colocalization of IFI30 with the endoplasmic reticulum (ER), indicating its predominant ER–lysosomal subcellular localization. E Analysis of the TCGA dataset showing significantly higher IFI30 expression in gastric cancer tissues versus normal gastric tissues, validated by paired-sample analysis; receiver operating characteristic (ROC) curve analysis demonstrating strong diagnostic performance of IFI30 expression for distinguishing STAD from normal gastric tissues (AUC = 0.92; 95% CI: 0.89–0.95). Statistical significance: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
Article Snippet: D Immunofluorescence images from the Human Protein Atlas (HPA) showing robust colocalization of IFI30 with the endoplasmic reticulum (ER), indicating its predominant ER–lysosomal subcellular localization.
Techniques: Expressing, Diagnostic Assay, Immunofluorescence